Area of research
Epidemiology · Oncology
Research interest
Research interests include Cytomegalovirus and herpesvirus research, Herpesvirus Infections and Treatments, Viral-associated cancers and disorders, and Toxoplasma gondii Research Studies.
Host cell Z-RNAs activate ZBP1 during virus infections
Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency
KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis
Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis
Viral Z-RNA triggers ZBP1-dependent cell death
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway
Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection
Competition between E3 and ZBP1 for Z-RNA Dictates Susceptibility to Vaccinia Virus-Induced Necroptosis
Caspase-8 restricts antiviral CD8 T cell hyperaccumulation
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock
Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1
Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3
Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus
A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus–Seronegative Men
Herpes Simplex Virus Suppresses Necroptosis in Human Cells
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus
Necroptosis: The Trojan horse in cell autonomous antiviral host defense
Manipulation of apoptosis and necroptosis signaling by herpesviruses
The A, B, Cs of Herpesvirus Capsids
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice