Area of research
Physiology · Neurology
Research interest
Research interests include Alzheimer's disease research and treatments, Amyotrophic Lateral Sclerosis Research, Mitochondrial Function and Pathology, and Endoplasmic Reticulum Stress and Disease.
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
Disruption of ER‐mitochondria tethering and signalling in <i>C9orf72</i>‐associated amyotrophic lateral sclerosis and frontotemporal dementia
Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein
Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis
Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
FE65 interacts with ADP‐ribosylation factor 6 to promote neurite outgrowth
Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria