Area of research
Spectroscopy · Organic Chemistry
Research interest
Research topics from publications: Less is More: A Shortcut for Anionocages Design Based on (RPO32−)‐Monourea Coordination; Stereoselective Assembly of Hydrogen‐Bonded Anionic Cages Dictated by Organophosphate‐Based Chiral Nodes. Representative work: Abstract Anionocages have been developed as a unique family of hydrogen bonded cages. However, strategies for constructing anionocages are mainly limited to that based on (PO 4 3− )‐bisurea coordination, neither the ligands nor the anions lack the simplicity and diversity of the maturely developed analogues based on metal coordination (i.e. metallocage). We report herein a more simple strategy for anionocages design based on (RPO 3 2− )‐monourea coordination, utilizing monourea rather than bisurea as the hydrogen binding donor, and RPO 3 2− rather than PO 4 3− as the acceptor. Two fluorescent, quadruple helicate anionocages were constructed by a bis‐monourea ligand, and dianions PhOPO 3 2− ( Inspired by the signal transduction function of organophosphates in biological systems, bioactive organophosphates were utilized for the first time as chiral nodes to dictate the stereoselective assembly of hydrogen-bonded anionic cages. Phosphonomycin (antibiotics), tenofovir (antivirals), adenosine monophosphate (natural product, AMP) and clindamycin phosphate (antibiotics) were assembled with an achiral bis-monourea ligand, thereby leading to the stereoselective formation of quadruple or triple helicates. The extent of the stereoselectivity could be enhanced by either lowering the temperature or adding stronger-binding cations as templates. With the chiral anionic cages as the host, some