Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, CRISPR and Genetic Engineering, and MicroRNA in disease regulation.
Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses
Nucleic acid-based drugs for patients with solid tumours
Drug delivery systems for CRISPR-based genome editors
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
The NIH Somatic Cell Genome Editing program
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension
Using Large Datasets to Understand Nanotechnology
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Emerging Frontiers in Drug Delivery
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
DSpace@MIT (Massachusetts Institute of Technology) 2016cited by 2position: middle
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
Challenges in carrier‐mediated intracellular delivery: moving beyond endosomal barriers
Dendrimer-Inspired Nanomaterials for the <i>in Vivo</i> Delivery of siRNA to Lung Vasculature
Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Small RNA combination therapy for lung cancer
Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo