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Alexander E. Perl

Hospital of the University of Pennsylvania · US
Area of research
Hematology · Genetics
Research interest
Research interests include Acute Myeloid Leukemia Research, Chronic Myeloid Leukemia Treatments, Chronic Lymphocytic Leukemia Research, and Protein Degradation and Inhibitors.
h-index
55
citations
15,887
works
414
NIH funding
primary concept
Medicine
email

Recent publications

Menin inhibition with revumenib for <i>NPM1</i>-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study
Blood 2025cited by 40position: middledoi
Measurable residual disease and posttransplantation gilteritinib maintenance for patients with <i>FLT3-ITD</i>–mutated AML
Blood 2025cited by 30position: middledoi
Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3–internal tandem duplications in the QuANTUM-First trial
Haematologica 2025cited by 6position: middledoi
<i>FLT3</i> -ITD measurable residual disease from the QuANTUM-First trial
Blood Advances 2025cited by 3position: lastdoi
QuANTUM-Wild: A phase 3, randomized, double-blind, placebo-controlled trial of quizartinib in combination with chemotherapy and as single-agent maintenance in <i>FLT3</i> -ITD–negative acute myeloid leukemia (AML).
Journal of Clinical Oncology 2025cited by 2position: middledoi
Effect of FLT3 maintenance in older FLT3-ITD+ adults undergoing allogeneic HCT. a post hoc analysis of BMT CTN 1506
Blood 2025cited by 1position: middledoi
Gilteritinib as Post-Transplant Maintenance for AML With Internal Tandem Duplication Mutation of <i>FLT3</i>
Journal of Clinical Oncology 2024cited by 177position: middledoi
Menin Inhibition With Revumenib for <i>KMT2A</i> -Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101)
Journal of Clinical Oncology 2024cited by 169position: middledoi
A phase 1 study of the irreversible FLT3 inhibitor FF-10101 in relapsed or refractory acute myeloid leukemia
Blood Advances 2024cited by 21position: middledoi
Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia
Nature Communications 2024cited by 15position: middledoi
Updated Results and Longer Follow-up from the AUGMENT-101 Phase 2 Study of Revumenib in All Patients with Relapsed or Refractory (R/R) <i>KMT2Ar</i> Acute Leukemia
Blood 2024cited by 13position: middledoi
Trial in Progress: The Phase 3, Randomized, Double-Blind, Placebo-Controlled QuANTUM-Wild Study of Quizartinib in Combination With Chemotherapy and as Single-Agent Maintenance in Newly Diagnosed, <i>FLT3</i>-ITD-Negative Acute Myeloid Leukemia
Blood 2024cited by 7position: middledoi
Correlation of Baseline Gene Mutations With Quizartinib Efficacy in Patients With <i>FLT3</i>-ITD-Positive Newly Diagnosed Acute Myeloid Leukemia in the Phase 3 QuANTUM-First Trial
Blood 2024cited by 2position: middledoi
Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet 2023cited by 351position: middledoi
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology
Journal of the National Comprehensive Cancer Network 2023cited by 174position: middledoi
Gilteritinib in Combination With Induction and Consolidation Chemotherapy and as Maintenance Therapy: A Phase IB Study in Patients With Newly Diagnosed AML
Journal of Clinical Oncology 2023cited by 43position: middledoi
Revumenib Monotherapy in Patients with Relapsed/Refractory <i>KMT2Ar</i> Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study
Blood 2023cited by 22position: middledoi
Revumenib Monotherapy in Patients with Relapsed/Refractory <i>KMT2Ar</i> Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study
Blood 2023cited by 18position: middledoi
Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( <i>FLT3</i>-ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) <i>FLT3</i>-ITD+ AML Patients (pts)
Blood 2023cited by 4position: firstdoi
P483: QUANTUM-FIRST TRIAL: FLT3-ITD–SPECIFIC MEASURABLE RESIDUAL DISEASE (MRD) CLEARANCE IS ASSOCIATED WITH IMPROVED OVERALL SURVIVAL
HemaSphere 2023cited by 3position: lastdoi
Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( <i>FLT3</i>-ITD) Positive Acute Myeloid Leukemia (AML)
Blood 2023cited by 2position: middledoi
CT-186 Impact of Allogeneic Hematopoietic Cell Transplantation (allo-HCT) in First Complete Remission (CR1) in Addition to FLT3 Inhibition With Quizartinib in Acute Myeloid Leukemia (AML) With FLT3–Internal Tandem Duplication (FLT3-ITD): Results from the QuANTUM-First Trial
Clinical Lymphoma Myeloma & Leukemia 2023cited by 1position: middledoi
Oral Abstract: CT-186 Impact of Allogeneic Hematopoietic Cell Transplantation (allo-HCT) in First Complete Remission (CR1) in Addition to FLT3 Inhibition with Quizartinib in Acute Myeloid Leukemia (AML) with FLT3–Internal Tandem Duplication (FLT3-ITD): Results from the QuANTUM-First Trial
Clinical Lymphoma Myeloma & Leukemia 2023cited by 1position: middledoi
Kinetics of Complete Remission (CR) and CR Duration and Its Impact on Overall Survival (OS) and Event-Free Survival (EFS) in Quantum-First
Blood 2023cited by 1position: middledoi
Venetoclax Plus Gilteritinib for <i>FLT3</i>-Mutated Relapsed/Refractory Acute Myeloid Leukemia
Journal of Clinical Oncology 2022cited by 184position: middledoi
Follow-up of patients with R/R <i>FLT3-</i>mutation–positive AML treated with gilteritinib in the phase 3 ADMIRAL trial
Blood 2022cited by 136position: firstdoi
Molecular profile of <i>FLT3</i>-mutated relapsed/refractory patients with AML in the phase 3 ADMIRAL study of gilteritinib
Blood Advances 2022cited by 83position: middledoi
North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need
Blood 2022cited by 56position: middledoi
Clinical outcomes in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia treated with gilteritinib who received prior midostaurin or sorafenib
Blood Cancer Journal 2022cited by 44position: firstdoi
Outcomes in Patients with FLT3-Mutated Relapsed/ Refractory Acute Myelogenous Leukemia Who Underwent Transplantation in the Phase 3 ADMIRAL Trial of Gilteritinib versus Salvage Chemotherapy
Transplantation and Cellular Therapy 2022cited by 38position: firstdoi

Grants

No grants ingested yet.

Frequent collaborators

Mark J. Levis · University of Turin53 papers (2012–2025)Jörge E. Cortes · Cecil College31 papers (2012–2025)Pau Montesinos · Hospital Universitari i Politècnic La Fe24 papers (2018–2025)Hervé Dombret · University of London Institute in Paris21 papers (2012–2025)Catherine C. Smith · University of San Francisco19 papers (2012–2024)Harry P. Erba · Duke University18 papers (2016–2025)Richard F. Schlenk · Institute of Human Genetics17 papers (2021–2025)Arnaud Lesegretain · Daiichi Sankyo (United States)17 papers (2019–2025)Alwin Krämer · German Cancer Research Center14 papers (2018–2020)Mikkael A. Sekeres · Yale University13 papers (2022–2025)Jianxiang Wang · Zhejiang University13 papers (2022–2025)Hee‐Je Kim · St. Mary's Hospital13 papers (2022–2025)Jessica K. Altman · Northwestern University13 papers (2015–2024)Nigel H. Russell · University of Nottingham13 papers (2018–2020)Elżbieta Patkowska · Institute for Transfusion Medicine12 papers (2022–2025)Sergio Amadori · Duke Cancer Institute12 papers (2022–2025)Samer K. Khaled · University of Kansas12 papers (2018–2020)Siddhartha Ganguly · Cancer Clinic12 papers (2018–2020)Gary J. Schiller · APLA Health12 papers (2015–2024)Yasser Mostafa Kamel · Daiichi Sankyo (United States)11 papers (2022–2025)