Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Neuroscience and Neuropharmacology Research, Receptor Mechanisms and Signaling, Neuroinflammation and Neurodegeneration Mechanisms, and Pharmacological Receptor Mechanisms and Effects.
The adamantane scaffold: Beyond a lipophilic moiety
Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19: A TSPO PET Study
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma
Emerging TSPO-PET Radiotracers for Imaging Neuroinflammation: A Critical Analysis
Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece
Unlocking therapeutic potential: the role of adamantane in drug discovery
Late-stage Functionalization for Improving Drug-like Molecular Properties
An update on late-stage functionalization in today’s drug discovery
Three‐dimensional bioprinting of stem cell‐derived central nervous system cells enables astrocyte growth, vasculogenesis, and enhances neural differentiation/function
Imaging Brain Injury in Former National Football League Players
Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery
Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature
Neuroinflammation in frontotemporal dementia
Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders
An overview of late-stage functionalization in today’s drug discovery
<i>O</i>-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease
Challenges and Opportunities in Central Nervous System Drug Discovery
The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
In vitro determination of the efficacy of illicit synthetic cannabinoids at CB <sub>1</sub> receptors
Cubanes in Medicinal Chemistry
Peptides, Peptidomimetics, and Carbohydrate–Peptide Conjugates as Amyloidogenic Aggregation Inhibitors for Alzheimer’s Disease
In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of <i>Plasmodium</i> M1 and M17 Aminopeptidases