Area of research
Genetics · Physiology
Research interest
Research topics from publications: Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes; The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy; Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4+ T cells in patients with primary Sjögren's syndrome; Induced pluripotent stem cell-derived mesenchymal stem cells: whether they can become new stars of cell therapy; Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment; Clinical application of mesenchymal stem cells in rheumatic diseases; Bibliometric and visualization analysis of mesenchymal stem cells and rheumatoid arthritis (from 2012 to 2021); Carbon dots as a new class of multifunctional nanomaterial in mesenchymal stem cells: opportunities and challenges; Increased m6A RNA methylation and METTL3 expression may contribute to the synovitis progression of rheumatoid arthritis; Psoriasis and gut microbiota: A Mendelian randomization study. Representative work: With the continuous improvement of human technology, the medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell therapy has successfully created a research boom in the modern medical field. Mesenchymal stem cells (MSCs) are derived from early mesoderm and have high self-renewal and multidirectional differentiation ability, and have become one of the important cores of cell therapy research by virtue of their immunomodulatory and tissue repair capabilities. In recent years, the application of MSCs in various diseases has received widespread attention, but there are still various problems in the treatment of MSCs, among whic Abstract Background Primary Sjögren's syndrome (pSS) is an autoimmune disease that leads to the destruction of exocrine glands and multisystem lesions. Abnormal proliferation, apoptosis, and differentiation of CD4 + T cells are key factors in the pathogenesis of pSS. Autophagy is one of the important mechanisms to maintain immune homeostasis and function of CD4 + T cells. Human umbilical cord mesenchymal stem cell-derived exosomes (UCMSC-Exos) may simulate the immunoregulation of MSCs while avoiding the risks of MSCs treatment. However, whether UCMSC-Exos can regulate the functions of CD4 + T cells in pSS, and whether t
Bioinspired Carbon Dots with Multi‐Enzyme Activity, Single‐Atom Catalytic, High Efficiency ROS Scavenging and Antioxidant Therapy for Rheumatoid Arthritis
Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders
Comparative Effectiveness of Tocilizumab vs Rituximab in Rheumatoid Arthritis-Associated Interstitial Lung Disease
Induced pluripotent stem cell-derived mesenchymal stem cells: whether they can become new stars of cell therapy
Increased m6A RNA methylation and METTL3 expression may contribute to the synovitis progression of rheumatoid arthritis
The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy
Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4+ T cells in patients with primary Sjögren's syndrome
Carbon dots as a new class of multifunctional nanomaterial in mesenchymal stem cells: opportunities and challenges
Psoriasis and gut microbiota: A Mendelian randomization study
Quantitative and biosafe modification of bifunctional groups onto carbon dots by click chemistry
Genetically predicted 486 blood metabolites concerning risk of systemic lupus erythematosus: a Mendelian randomization study
Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
Bibliometric and visualization analysis of mesenchymal stem cells and rheumatoid arthritis (from 2012 to 2021)
Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes
Clinical application of mesenchymal stem cells in rheumatic diseases
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer’s disease