Area of research
Cell Biology · Atomic and Molecular Physics, and Optics
Research interest
Research interests include Extracellular matrix, Biophysics, Cell biology, Biology, Integrin, and Rigidity (electromagnetism).
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing
The laminin–keratin link shields the nucleus from mechanical deformation and signalling
Mechanical force application to the nucleus regulates nucleocytoplasmic transport
Cardiac fibroblasts and mechanosensation in heart development, health and disease
Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer
The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
The mechanical stability of proteins regulates their translocation rate into the cell nucleus
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
Force loading explains spatial sensing of ligands by cells
Membrane tension controls adhesion positioning at the leading edge of cells
α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions
Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices
Physical principles of membrane remodelling during cell mechanoadaptation
Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation
Cells test substrate rigidity by local contractions on submicrometer pillars
Finding the weakest link – exploring integrin-mediated mechanical molecular pathways