Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Sphingolipid Metabolism and Signaling, Melanoma and MAPK Pathways, Endoplasmic Reticulum Stress and Disease, and Cancer, Hypoxia, and Metabolism.
Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis
Endothelial metabolic control of insulin sensitivity through resident macrophages
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention
A new type of blood–brain barrier aminoacidopathy underlies metabolic microcephaly associated with <i>SLC1A4</i> mutations
CERT1 mutations perturb human development by disrupting sphingolipid homeostasis
Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies
Recurrent<i>de-novo gain-of-function</i>mutation in<i>SPTLC2</i>confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
Genetic pain loss disorders
Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration
Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis
Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases**
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
A global lipid map defines a network essential for Zika virus replication
Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases
Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics
Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids
Synthesis and characterization of some atypical sphingoid bases
Frequent genes in rare diseases: panel‐based next generation sequencing to disclose causal mutations in hereditary neuropathies
Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol
Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction
Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway
Elucidating the chemical structure of native 1-deoxysphingosine