Area of research
Surgery · Radiology, Nuclear Medicine and Imaging
Research interest
My most recent clinical research focuses on the clinical impact of silent embolic events and consequences on neurocognitive function following transcatheter aortic valve replacement (TAVR) procedures. Our recently completed NeuroTAVR US registry demonstrated that >95% of patients following TAVR have new silent ischemic lesions detected by cerebral diffusion-weighted imaging. Our European DEFLECT I trial demonstrated a 65% to 95% reduction in the volume of brain lesions with the use of a neuro-deflection device anchored in the aortic arch compared to historic controls. The DEFLECT III multicenter randomized trial confirmed a 40% reduction in DWI brain lesion volume and number as well as neurologic injury and cognitive improvement with neuroprotection compared to no protection.
Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement: The DEFINE-TAVR Prospective Study
Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial
Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Surgical Risk and Long-Term Mortality With PCI and CABG in Ischemic Left Ventricular Systolic Dysfunction
Characteristics and Outcomes of Older Patients Undergoing Protected Percutaneous Coronary Intervention With Impella.
Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study.
Pitfalls in Comparing Mechanical Circulatory Support Devices Using Administrative Datasets: Epidemiology of the Diseased Population.
Safety and Efficacy of Percutaneous Ventricular Assist Device vs Intra-Aortic Balloon Pump in Elective High-Risk Percutaneous Coronary Intervention Procedures.
Safety and Efficacy of Endovascular Treatment Modalities for Below-the-Knee Arterial Disease: A Systematic Review and Network Meta-analysis.
Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device-Supported High-Risk Percutaneous Coronary Intervention: The PROTECT III Study.
Expected Surgical Risk and the Risk of Stroke and Brain Injury After Transcatheter Aortic Valve Replacement: A Patient-Level Pooled Analysis
Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Trials.
Approval, Evidence, and "Off-Label" Device Utilization: The Patent Foramen Ovale Closure Story.
Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review.
Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study.
A Safety and Feasibility Single-Arm Study of a Novel Catheter Thrombectomy Device for the Treatment of Pulmonary Embolism (ENGULF)
Long-Term Percutaneous Coronary Intervention Outcomes in Chronic Versus Acute Coronary Syndromes (TARGET All Comers Trial).
Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study.
Periprocedural myocardial infarction: thresholds of (in)significance.
Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries.
Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
<i>JSCAI</i> Reaches Another Milestone: We Are Indexed in PubMed Central.
Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
STICH3C: Rationale and Study Protocol
Cerebral embolic protection during transcatheter heart interventions
Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial.
Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study.
Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies.
Impact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study.