Area of research
Physiology · Molecular Biology
Research interest
Dr. Cooke’s research program is focused on vascular regeneration, vascular cell identity and cell fate. The program is funded by grants from the National Institutes of Health, the American Heart Association, Cancer Prevention Research Institute, and industry. The Cooke group aims to understand the mechanisms underlying epigenetic plasticity that are required for functional adaptation to cellular challenges. Innate immune signaling causes global changes in the expression and activity of epigenetic modifiers with metabolic coupling that favors an open chromatin configuration. The translational output of this work is vascular regeneration via therapeutic transdifferentiation using small molecules or mRNA. In his 25 years of translational vascular biology, Dr. Cooke first described and charact
Telomerase mRNA therapy protects human skin against radiation-induced DNA damage
Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair.
Recovery From Heart Failure: Microvascular Mechanisms.
Human BMP4 mRNA Encapsulated in Lipid Nanoparticle Delayed Cartilage Degeneration but Has a Limited Enhancement Effect on Bone Healing in Aged Mice
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‐enabling studies in a human vessel‐chip: Are we there yet?
A Long-lived Avatar for Modeling Age-Related Vascular Disease
Telomerase is induced during wound healing across species
A visual–omics foundation model to bridge histopathology with spatial transcriptomics
Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Thor: a platform for cell-level investigation of spatial transcriptomics and histology.
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria.
APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling.
Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation
Telomerase mRNA Reduces Radiation-induced DNA Damage of human skin
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.
Next-generation precision medicine for suicidality prevention
Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing.
Established and Emerging Nucleic Acid Therapies for Familial Hypercholesterolemia.
Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial.
Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation.
Recovery from Heart Failure is a Vascular Recovery
A relay velocity model infers cell-dependent RNA velocity
Epigenetic landscape reveals MECOM as an endothelial lineage regulator.
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis.
Disrupted Stiffness Ratio Alters Nuclear Mechanosensing.
Is Cardiovascular Regeneration Possible?