Area of research
Neurology · Cell Biology
Research interest
Research interests include Parkinson's Disease Mechanisms and Treatments, Cellular transport and secretion, Alzheimer's disease research and treatments, and Lysosomal Storage Disorders Research.
Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
α-Synuclein in synaptic function and dysfunction
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information
The complexity of tau in Alzheimer’s disease
Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease
Definition of a Molecular Pathway Mediating α-Synuclein Neurotoxicity
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
Microsecond Dissection of Neurotransmitter Release: SNARE-Complex Assembly Dictates Speed and Ca2+ Sensitivity
Synaptic function of nicastrin in hippocampal neurons
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
Properties of native brain α-synuclein
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration