Area of research
Molecular Biology · Genetics
Research interest
Research interests include Cancer therapeutics and mechanisms, DNA Repair Mechanisms, DNA and Nucleic Acid Chemistry, and Bacterial Genetics and Biotechnology.
A high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions
Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA
Chromatin buffers torsional stress during transcription
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II
Chromatinization modulates topoisomerase II processivity
Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67
Structural and functional characterization of the Spo11 core complex
Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast
A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome
Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II
A new class of disordered elements controls DNA replication through initiator self-assembly
Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity
A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents
Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein
Mechanisms for initiating cellular DNA replication
Mechanisms and regulation of DNA replication initiation in eukaryotes
Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from <i>Mycobacterium tuberculosis</i>
<i>IOTA</i>: integration optimization, triage and analysis tool for the processing of XFEL diffraction images
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
Crystal structure of the eukaryotic origin recognition complex
A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions
Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
Nucleotide and Partner-Protein Control of Bacterial Replicative Helicase Structure and Function
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
Binding Mechanism of Metal⋅NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases
Bayesian Analysis and Interfaces
Collaborative Research: Bayesian Analysis and Applications
Workshop on Data-Enabled Science
Statistical and Applied Mathematical Sciences Institute
Bayesian Analysis and Frequentist Interfaces
Bayesian Analysis, Decision Theory, and Applications
Group Travel Award to the 6th Valencia International Meeting on Bayesian Statistics to be held in Ibiza, Spain on June 6-10, 1998
Mathematical Sciences: Conference on Multiple Decision Theory and Related Topics
Mathematical Sciences:Group Travel Award to the 5th International meeting on "Bayesian Statistics"; June 5-10, 1994; Alicante, Spain
Mathematical Sciences: Investigations in Bayesian Analysis,Statistical Decision Theory, and Computation
Mathematical Sciences: Group Travel Award for the 4th Valencia International Meeting on Bayesian Statistics, Peniscola, Spain, April 15-20, 1991
Mathematical Sciences: Investigations in Bayesian Analysis, Statistical Decision Theory and Computation
Mathematical Sciences: Investigations in Statistical Decision Theory, Bayesian Analysis, Probability and Computation
Bayesian Statistics: Robust Analysis and Reference Priors; U.S.-Spain Program
Mathematical Sciences: Investigation in Statistical Decision Theory and Bayesian Analysis
Investigations in Statistical Decision Theory
Investigations in Decision Theory
Improving on Multivariate Estimators
Admissibility Questions in Location Parameter Problems of Statistical Decision Theory