Area of research
Molecular Biology · Immunology
Research interest
Research interests include Immune Response and Inflammation, Inflammasome and immune disorders, Cell death mechanisms and regulation, and Gut microbiota and health.
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy
Host–microbiota interactions in inflammatory bowel disease
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Neonatal acquisition of <i>Clostridia</i> species protects against colonization by bacterial pathogens
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mechanism and Regulation of NLRP3 Inflammasome Activation
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Mechanisms of inflammation-driven bacterial dysbiosis in the gut
Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling
IKKα negatively regulates ASC-dependent inflammasome activation
Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3
IL-18 is not therapeutic for neovascular age-related macular degeneration
Role of the gut microbiota in immunity and inflammatory disease
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Control of pathogens and pathobionts by the gut microbiota
A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection
Understanding the microbiota in the midst of Renaissance architecture and olive groves
Sensing and reacting to microbes through the inflammasomes
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy
The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Antibacterial Function in Human Intestinal Epithelial Cells