Area of research
Immunology · Oncology
Research interest
My laboratory examines how specialized lineages of the immune system develop to anticipate various types of infections and to generate the correct quality of immune response. Our initial focus examined the basis of CD4 T cell development into the function helper subsets, such as TH1, TH2,TH17, and so on. Our work defined the physiological basis of instructive differentiation that occurs in response to pathogens and defined the signaling pathways and transcriptional circuits involved. Our early discovery that dendritic cells and macrophages determined the direction of T cell differentiation, by their production of cytokines such as IL-12, led us to examine how myeloid cells evolved to be the decision makers for T cell differentiation in immunity.
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8 <sup>+</sup> T cell responses against an arthritogenic alphavirus
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
Genetic models of human and mouse dendritic cell development and function
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity
Chikungunya Virus Evades Antiviral CD8<sup>+</sup>T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells
An Important Role for CD4 <sup>+</sup> T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification
An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development
Models of dendritic cell development correlate ontogeny with function
Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development
WDFY4 is required for cross-presentation in response to viral and tumor antigens
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections
Notch2-dependent DC2s mediate splenic germinal center responses
Altered compensatory cytokine signaling underlies the discrepancy between <i>Flt3–/–</i> and <i>Flt3l–/–</i> mice
<i>Batf3</i>-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation
Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin
Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells during an Immune Response
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF–IRF4 transcription factor complex
The role of cDC1s in vivo: CD8 T cell priming through cross-presentation
Opposing Roles of Dendritic Cell Subsets in Experimental GN
ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms
Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice