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James R. Broach

Princeton University · US
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Area of research
Molecular Biology · Genetics
Research interest
Research interests include Biology, Computational biology, Amyotrophic lateral sclerosis, Frontotemporal dementia, Single-nucleotide polymorphism, and RNA splicing.
h-index
citations
1,958
works
13
NIH funding
primary concept
email

Recent publications

TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience 2025cited by 16position: middledoi
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature 2024cited by 4position: middledoi
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature 2022cited by 499position: middledoi
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
Communications Biology 2022cited by 50position: middledoi
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
iScience 2021cited by 49position: middledoi
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever
npj Biofilms and Microbiomes 2021cited by 15position: middledoi
An integrative ENCODE resource for cancer genomics
Nature Communications 2020cited by 183position: middledoi
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Nature Medicine 2020cited by 162position: middledoi
<i>Paenibacillus</i> infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
Science Translational Medicine 2020cited by 55position: middledoi
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Cell Reports 2019cited by 328position: middledoi
An integrative ENCODE resource for cancer genomics
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 15position: middledoi
Integrative detection and analysis of structural variation in cancer genomes
Nature Genetics 2018cited by 493position: middledoi
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
eLife 2018cited by 87position: middledoi
An Integrative Framework for Detecting Structural Variations in Cancer Genomes
bioRxiv (Cold Spring Harbor Laboratory) 2017cited by 17position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

· 1 papers (2021–2021)Rafael A. Irizarry · Harvard University1 papers (2021–2021) · 1 papers (2021–2021)Mercedeh Movassagh · Georgetown University1 papers (2021–2021) · 1 papers (2021–2021) · 1 papers (2021–2021) · 1 papers (2021–2021)Christine Hehnly · Pennsylvania State University1 papers (2021–2021)Joseph N. Paulson · Exelixis (United States)1 papers (2021–2021)Joseph Ngonzi · University of Antwerp1 papers (2021–2021)Kathryn Sheldon · Pennsylvania State University1 papers (2021–2021)Frederick A. Meier · Virginia Commonwealth University1 papers (2021–2021)Lijun Zhang · Heilongjiang Institute of Wood Science1 papers (2021–2021)Peter Olupot‐Olupot · London School of Hygiene & Tropical Medicine1 papers (2021–2021)Andrew Weeks · University of Liverpool1 papers (2021–2021)Lisa M. Bebell · Harvard University1 papers (2021–2021) · 1 papers (2021–2021)Steven J. Schiff · Pennsylvania State University1 papers (2021–2021)Melissa Gladstone · University of Liverpool1 papers (2021–2021)Drucilla J. Roberts · Harvard University1 papers (2021–2021)
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