Area of research
Molecular Biology
Research interest
Research interests include DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA Interference and Gene Delivery, and RNA and protein synthesis mechanisms.
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer.
Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues.
Dissecting the Binding Interactions of the Chromatin Remodeler SMARCA4 with G-Quadruplex DNA.
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras.
Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.
Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch
KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency
Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch.
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands.
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands
Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA.
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA
Selective Photocatalytic C-H Oxidation of 5-Methylcytosine in DNA.
Commentary on 'Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments'.
Cryo-EM structures of NHEJ assemblies with nucleosomes.
Commentary on ‘Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments’
G-quadruplex DNA structure is a positive regulator of <i>MYC</i> transcription.
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription
An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription.
Quantum computation from dynamic automorphism codes
Glassy Word Problems: Ultraslow Relaxation, Hilbert Space Jamming, and Computational Complexity
Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR.
Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues
Selective Photocatalytic C−H Oxidation of 5‐Methylcytosine in DNA
Simultaneous sequencing of genetic and epigenetic bases in DNA
Simultaneous sequencing of genetic and epigenetic bases in DNA.
Chem-map profiles drug binding to chromatin in cells
Floquet Codes without Parent Subsystem Codes