Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Epilepsy research and treatment, and Intracerebral and Subarachnoid Hemorrhage Research.
Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils
Characterization of cerebellar amyloid-β deposits in Alzheimer disease
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
Improving Workflow Integration with xPath: Design and Evaluation of a Human-AI Diagnosis System in Pathology
Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures
Arteriolar neuropathology in cerebral microvascular disease
Single-cell RNA sequencing in silent corticotroph tumors confirms impaired POMC processing and provides new insights into their invasive behavior
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update
Inhibition of synucleinopathic seeding by rationally designed inhibitors
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease
Abstract WP66: Impaired Collaterals Are Associated With Intracranial Thrombus Extension: Evidence From MRI, Catheter Angiography, and Retrieved Thrombus Composition
Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice
Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples
Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4
Review: Vascular dementia: clinicopathologic and genetic considerations
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias
The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
Glial function (and dysfunction) in the normal & ischemic brain
Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
Loss of <i>O</i> -GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration
Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice
Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database
Rasmussen encephalitis tissue transfer program