Area of research
Molecular Biology · Computational Theory and Mathematics
Research interest
Research interests include Heat shock proteins research, Computational Drug Discovery Methods, Endoplasmic Reticulum Stress and Disease, and Protein Structure and Dynamics.
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation
Stress biology: Complexity and multifariousness in health and disease
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
Targeting stressor-induced dysfunctions in protein–protein interaction networks via epichaperomes
The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
Disease‐specific interactome alterations via epichaperomics: the case for Alzheimer’s disease
Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
Paradigms for Precision Medicine in Epichaperome Cancer Therapy
Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma
The epichaperome is an integrated chaperome network that facilitates tumour survival
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models
Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species
Abstract 1435: Role of PRKD2 in HSP90- and hypoxia-mediated epithelial-to-mesenchymal transition
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions
HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Abstract 5129: Role of PRKD2 in HSP90 inhibition-mediated suppression of cancer growth
Protein kinase D2 modulates tumor growth and tumor angiogenic programme induced by heat shock protein 90
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2