Lauren Cole

Area of research

Molecular Biology · Genetics

Research interest

Research topics from publications: Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells; Commentary: Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy; MNase Profiling of Promoter Chromatin in Salmonella typhimurium -Stimulated GM12878 Cells Reveals Dynamic and Response-Specific Nucleosome Architecture; MNase profiling of promoter chromatin in S. typhimurium -stimulated GM12878 cells reveals dynamic and response-specific nucleosome architecture; Chromatin-mediated Response to Stimuli. Representative work: Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity. The histone variant H2A.Z has been shown to contribute to this regulation, but its role has remained poorly understood. Here, we prepare high-depth maps of the position and accessibility of H2A.Z-containing nucleosomes for all human Pol II promoters in epithelial, mesenchymal and isogenic cancer cell lines. We find that, in contrast to the prevailing model, many different types of active and inactive promoter structures are observed that differ in their nucleosome organization and sensitivity to MNase digestion. Key aspects of an active chromatin structure include positioned H2A.Z MNase resistant nuc Keywords: cardiac troponin, dilated cardiomyopathy, disease, epigenetic gene regulation, heart, histone methylation, induced pluripotent stem cell, inherited cardiomyopathies, muscle, mutations, myosin, nucleus, state, stem-cells, tropomyosin, troponin T

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