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Lily Yeh Jan

Howard Hughes Medical Institute · US
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Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Ion channel regulation and function, Neurobiology and Insect Physiology Research, Neuroscience and Neuropharmacology Research, and Developmental Biology and Gene Regulation.
h-index
168
citations
80,470
works
596
NIH funding
primary concept
email

Recent publications

Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila
Neuron 2025cited by 1position: middledoi
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
Nature Cell Biology 2024cited by 46position: middledoi
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families
Nature Structural & Molecular Biology 2024cited by 23position: firstdoi
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling
Communications Biology 2024cited by 9position: lastdoi
Voltage sensors
Molecular Pharmacology 2024cited by 8position: firstdoi
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
Nature Communications 2023cited by 32position: lastdoi
Rare variants in <i>ANO1</i> , encoding a calcium-activated chloride channel, predispose to moyamoya disease
Brain 2023cited by 23position: middledoi
Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes
Molecular Cell 2022cited by 67position: middledoi
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling
The Journal of Cell Biology 2022cited by 8position: middledoi
Structure, function and pharmacology of human itch GPCRs
Nature 2021cited by 221position: middledoi
Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway
eLife 2021cited by 23position: middledoi
Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development
Digital Commons@Becker (Washington University School of Medicine) 2021cited by 12position: middle
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
Annual Review of Neuroscience 2020cited by 274position: middledoi
Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays
Nature Physics 2020cited by 98position: middledoi
TMEM16K is an interorganelle regulator of endosomal sorting
Nature Communications 2020cited by 55position: middledoi
Chloride channels regulate differentiation and barrier functions of the mammalian airway
eLife 2020cited by 34position: lastdoi
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
Neuron 2019cited by 210position: middledoi
Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
Cell Reports 2019cited by 121position: middledoi
The multifaceted role of TMEM16A in cancer
Cell Calcium 2019cited by 118position: lastdoi
Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area
Neuron 2019cited by 78position: lastdoi
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
Proceedings of the National Academy of Sciences 2019cited by 77position: lastdoi
Chemically induced vesiculation as a platform for studying TMEM16F activity
Proceedings of the National Academy of Sciences 2019cited by 47position: lastdoi
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity
eLife 2019cited by 31position: lastdoi
TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice
Journal of Neuroscience 2019cited by 25position: lastdoi
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala
eLife 2019cited by 23position: lastdoi
The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel
Neuron 2018cited by 99position: lastdoi
Activation of orexin system facilitates anesthesia emergence and pain control
Proceedings of the National Academy of Sciences 2018cited by 78position: lastdoi
Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F
Proceedings of the National Academy of Sciences 2018cited by 69position: lastdoi
Far away from the lamppost
PLoS Biology 2018cited by 13position: middledoi
Force-activated ion channels in close-up
Nature 2018cited by 4position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Yuh Nung Jan · University of California San Francisco Medical Center65 papers (2012–2025)Christian J. Peters · Illinois College10 papers (2012–2019)Tong Cheng · Xiamen University10 papers (2012–2025)Wenlei Ye · University of California, San Francisco10 papers (2017–2023)Shan Meltzer · Vanderbilt University8 papers (2012–2017)Wei Zhang · Guangdong Academy of Sciences8 papers (2012–2024)Jason Tien · Teva Pharmaceuticals (United States)7 papers (2012–2018)Peng Jin · Howard Hughes Medical Institute6 papers (2015–2025)Tina W. Han · University of California, San Francisco6 papers (2013–2023)Alma L. Burlingame · University of California, San Francisco6 papers (2012–2025)Huanghe Yang · Duke University6 papers (2012–2017)Mu He · Shaanxi University of Chinese Medicine6 papers (2017–2023)Susan Younger · Howard Hughes Medical Institute5 papers (2013–2025)Yanmeng Guo · Howard Hughes Medical Institute5 papers (2016–2025)Chun Han · Cornell University5 papers (2012–2015)Fen Huang · University of California, San Francisco5 papers (2012–2014)David Gorczyca · Howard Hughes Medical Institute4 papers (2012–2017)Shengjie Feng · Howard Hughes Medical Institute4 papers (2017–2025)Kexin Li · Shenyang Pharmaceutical University4 papers (2019–2021)Zhenhao Guo · Fudan University4 papers (2015–2017)
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