Area of research
Molecular Biology · Toxicology
Research interest
Research interests include Topoisomerase, Quinolone, DNA gyrase, Chemistry, Topoisomerase IV, and DNA.
Professional Identity Formation of Basic Science Medical Educators: A Qualitative Study of Identity Supports and Threats
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
Activities of gyrase and topoisomerase IV on positively supercoiled DNA
Interactions between Quinolones and <i>Bacillus anthracis</i> Gyrase and the Basis of Drug Resistance
Activity of Quinolone CP-115,955 Against Bacterial and Human Type II Topoisomerases Is Mediated by Different Interactions
Topoisomerase II and leukemia
Bacillus anthracis GrlA <sup>V96A</sup> Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance
Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions
Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions