Jing Lian

Area of research

Biomaterials · Biomedical Engineering

Research interest

Research topics from publications: Photocross-linked silk fibroin/hyaluronic acid hydrogel loaded with hDPSC for pulp regeneration; Polydopamine-assisted immobilization of silk fibroin and its derived peptide on chemically oxidized titanium to enhance biological activity in vitro; A study on in vitro and in vivo bioactivity of silk fibroin / nano-hydroxyapatite / graphene oxide composite scaffolds with directional channels; Electrospun the oriented silk fibroin/ bioactive glass @ silk fibroin/ polycaprolactone composite bi-layered membranes for guided bone regeneration; Secretory breast carcinoma in a female adult with liver metastsis: a case report and literature review; Clinical-Pathologic Analysis of Breast Cancer With PIK3CA Mutations in Chinese Women; Retracted: Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold; Subclassifying triple-negative breast cancers and its potential clinical utility; Comparison of PD-L1 expression and MMR status between primary and matched metastatic lesions in patients with cervical cancer; Biomimetic Hydroxyapatite Composite Coatings with a Variable Morphology Mediated by Silk Fibroin and Its Derived Peptides Enhance the Bioactivity on Titanium. Representative work: BACKGROUND: Secretory breast carcinoma is an uncommon subset of breast cancer that usually has a favorable outcome. Although initially described in children, it also occurs in adults where it may metastasize, possibly resulting in death. To date, only 20 cases of secretory breast carcinoma with distant metastases have been described. CASE PRESENTATION: A 42-year-old female presented with liver metastasis after modified radical mastectomy of the left breast in 2008 at 34 years of age. The liver metastasis was morphologically similar to the primary tumor. Pan-TRK and Fluorescence in situ hybridization showed a rearrangement in the ETV6 gene. She subsequently underwent adjuvant chemotherapy wit PURPOSE: Mutations of PIK3CA have recently been shown to play an important role in the pathogenesis and progression of breast neoplasms. The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution of somatic PIK3CA mutation in Chinese breast cancer patients and explored their role in tumor phenotypes. METHODS: Mutational analysis of PIK3CA was done in 11

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