Area of research
Pediatrics, Perinatology and Child Health · Obstetrics and Gynecology
Research interest
Research topics from publications: Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage; Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway. Representative work: Unexplained recurrent miscarriage (RM) is a clinical challenge due to its unclear pathogenesis. TGFβ2 plays essential roles in reproductive events. Migrasomes are newly identified organelles. Herein, whether TGFβ2 might regulate trophoblast cell migrasome formation (MF) and miscarriage, and the epigenetic regulation mechanisms, is completely unknown. In this study, we find that TGFβ2-mediated MF is suppressed and is negatively associated with RM based on a case-control study, further confirmed by a mouse model with miscarriage. In cellular mechanism, TGFβ2 promotes trophoblast cell MF, specifically suppressed by lnc-HZ05. In details, lnc-HZ05 (1) suppresses FOXP3-mediated TGFβ2 transcription High incidence of unexplained miscarriage (UM) limits global human reproduction. Lithium (Li) batteries are widely used but rarely recycled, causing Li to spread into environments and enter human body. Notably, the healthy effects of Li exposure on UM are rarely explored. Herein, higher serum Li levels, villous tissue ferroptosis, and UM are associated. Exposure to high levels of Li causes placental ferroptosis to induce mouse miscarriage. Li exposure down-regulates ER levels to suppress ER-mediated METTL1 and MBOAT1 transcription, and also suppresses METTL1-mediated m7G modification on MBOAT1 mRNA to reduce MBOAT1 mRNA stability. Therefore, Li exposure causes ferroptosis in a GPX4-independe