Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Cellular Mechanics and Interactions, Cancer, Hypoxia, and Metabolism, Ion Transport and Channel Regulation, and Pancreatic function and diabetes.
Intracellular pH dynamics promotes zebrafish larval tail regeneration
Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells.
Author response: Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells
Intracellular pH dynamics regulates intestinal stem cell lineage specification
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Intracellular pH dynamics regulates intestinal stem cell lineage specification.
Author Reply to Peer Reviews of Arp2/3 Complex Activity Enables Nuclear YAP for Naive Pluripotency of Human Embryonic Stem Cells
pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells
β-Catenin is a pH sensor with decreased stability at higher intracellular pH
Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
Cell fate decisions: emerging roles for metabolic signals and cell morphology
The glycolytic enzyme phosphofructokinase-1 assembles into filaments
Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression
The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit
Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity
Ratiometric Imaging of pH Probes
Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function
pH sensing by FAK-His58 regulates focal adhesion remodeling
Electrostatics Control Actin Filament Nucleation and Elongation Kinetics