Area of research
Physiology · Cellular and Molecular Neuroscience
Research interest
My laboratory at Mayo Clinic (1976 to 1988) and at the University of California San Diego (1989-present) has been continuously involved in NIH-supported research on the mechanisms of pain and analgesia. Our work provided the first description of the specific analgesic actions of spinally-delivered drugs such as opiates and alpha 2 agonists and the complexity of spinal agents in specifically altering pain processing (>150 papers). My group has been very active with >850 papers, >46,000 citation in >20,000 papers. Several specific areas of our current research are noted. Role of immune signaling. We have an ongoing interest in the role played by inflammatory mediators and innate and adaptive immunity in pain processing. Our group demonstrated that KO of TLR4 signaling and spinal TLR4 blocker
Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy.
Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research
Editorial commitment to trust and integrity in science: implications for pain and anaesthesiology research*
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research
Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide
Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research
Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research.
12/15-lipoxygenases mediate toll-like receptor 4-dependent nociplastic pain hypersensitivity in female mice.
Neutrophil-neuronal crosstalk drives arthritis-induced pain
Human dorsal root ganglia neuronal cell line to study nociceptive signaling: a new pipeline for pain therapy
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research
Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research
CD163+ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier.
Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation
Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation.
The Polyanalgesic Consensus Conference (PACC)®: Intrathecal Drug Delivery Guidance on Safety and Therapy Optimization When Treating Chronic Noncancer Pain
The Polyanalgesic Consensus Conference (PACC)®: Updates on Clinical Pharmacology and Comorbidity Management in Intrathecal Drug Delivery for Cancer Pain
Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference.
Catheter Tip-Associated Mass With Continuous Infusion of Sufentanil for Persistent Spinal Pain Syndrome Type 2: A Case Report Including Histopathologic Examination and Review of the Associated Basic and Clinical Research.
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
Hydration‐Induced Void‐Containing Hydrogels for Encapsulation and Sustained Release of Small Hydrophilic Molecules
Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient