Area of research
Infectious Diseases · Materials Chemistry
Research interest
Research interests include HIV/AIDS drug development and treatment, Hepatitis C virus research, HIV Research and Treatment, and Crystallization and Solubility Studies.
Structural Aspects of Proline Methanologues in Drug Design, Optimization, and Development.
A Data-Driven Perspective on Bioisostere Evaluation: Mapping the Benzene Bioisostere Landscape with BioSTAR.
Carbon atom σ-hole tetrel bonding – a non-bonded interaction with potential application in drug design
Design, Synthesis, and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-986408.
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans.
Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937.
Applications of Bioisosteres in the Design of Biologically Active Compounds.
The pyridazine heterocycle in molecular recognition and drug discovery.
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
Sub-stoichiometric Modulation of Viral Targets-Potent Antiviral Agents That Exploit Target Vulnerability.
Some Observations and Guidance on Perspectives in the <i>Journal of Medicinal Chemistry</i>.
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.
Metallaphotoredox Decarboxylative Arylation of Natural Amino Acids via an Elusive Mechanistic Pathway
Advances in the synthesis of three-dimensional molecular architectures by dearomatizing photocycloadditions
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 2.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
Photo-Initiated Nickel Catalysis (PiNiC): Unmasking Dimethylnickel with Light
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access β-Hydrazino Ketone Motifs.
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate <i>C</i><sub>max</sub> and <i>C</i><sub>min</sub> by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.
Synthesis, Structure-Activity Relationships, and <i>In Vivo</i> Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.