Area of research
Rheumatology · Clinical Biochemistry
Research interest
Research interests include Folate and B Vitamins Research, Metabolism and Genetic Disorders, Esophageal and GI Pathology, and Epigenetics and DNA Methylation.
Folate Deficiency and/or the Genetic Variant Mthfr<sup>677C >T</sup> Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.
High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring
Severe Methylenetetrahydrofolate Reductase Deficiency