Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, CRISPR and Genetic Engineering, RNA modifications and cancer, and Acute Lymphoblastic Leukemia research.
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis
Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
Histidine catabolism is a major determinant of methotrexate sensitivity
Glyceraldehyde 3‐phosphate dehydrogenase modulates nonoxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
Sestrin2 is a leucine sensor for the mTORC1 pathway
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
Cancer Cell Metabolism: One Hallmark, Many Faces