Area of research
Molecular Biology · Oncology
Research interest
Research interests include Developmental Biology and Gene Regulation, Cancer Immunotherapy and Biomarkers, Monoclonal and Polyclonal Antibodies Research, and Cell Adhesion Molecules Research.
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells
Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
Structural basis of GPBAR activation and bile acid recognition
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells
Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
Structural basis of bile acid receptor activation and Gs coupling
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Inhibition of Delta-induced Notch signaling using fucose analogs
A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I
Structural basis for Notch1 engagement of Delta-like 4
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms