Area of research
Molecular Biology · Cancer Research · kum
Research interest
Research interests include MicroRNA in disease regulation, RNA Research and Splicing, RNA modifications and cancer, and RNA and protein synthesis mechanisms.
The biogenesis and regulation of animal microRNAs.
Exogenous RNA surveillance by proton-sensing TRIM25.
RNA stability enhancers for durable base-modified mRNA therapeutics.
ERH promotes primary microRNA processing beyond cluster assistance.
SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production.
Human cytomegalovirus long non-coding RNA counteracts nuclear cGAS to facilitate immune evasion.
Spatio-temporal proteomic profiling of SARS-CoV-2 replication organelles
Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site.
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution.
Structure of the human DICER-pre-miRNA complex in a dicing state.
Sequence determinant of small RNA production by DICER.
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex
Short poly(A) tails are protected from deadenylation by the LARP1-PABP complex.
Coordinate regulation of the senescent state by selective autophagy
The regulatory impact of RNA-binding proteins on microRNA targeting.
L1 retrotransposons exploit RNA m<sup>6</sup>A modification as an evolutionary driving force.
Photoactivatable ribonucleosides mark base-specific RNA-binding sites.
Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells.
The Architecture of SARS-CoV-2 Transcriptome
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing.
Quantification of purified endogenous miRNAs with high sensitivity and specificity.
Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution.
ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8
FAX-RIC enables robust profiling of dynamic RNP complex formation in multicellular organisms<i>in vivo</i>
The architecture of SARS-CoV-2 transcriptome
MS1-Level Proteome Quantification Platform Allowing Maximally Increased Multiplexity for SILAC and <i>In Vitro</i> Chemical Labeling.
The SARS-CoV-2 RNA interactome
L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development.