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Ruben Smith

Lund University · SE
Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Functional Brain Connectivity Studies, and Medical Imaging Techniques and Applications.
h-index
60
citations
17,404
works
285
NIH funding
primary concept
Medicine
email

Recent publications

Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform
Nature Medicine 2025cited by 113position: middledoi
Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
JAMA 2025cited by 37position: middledoi
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Nature Neuroscience 2025cited by 30position: middledoi
Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data
Alzheimer s & Dementia 2025cited by 21position: middledoi
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Brain 2025cited by 6position: middledoi
Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment
JAMA Neurology 2024cited by 55position: middledoi
Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model
Alzheimer s & Dementia 2024cited by 43position: middledoi
Head‐to‐Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study
Annals of Neurology 2024cited by 8position: middledoi
Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies
JAMA Neurology 2023cited by 143position: middledoi
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases
Nature Communications 2023cited by 133position: firstdoi
Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis
Brain 2023cited by 46position: middledoi
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
Nature Medicine 2022cited by 468position: middledoi
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Nature Medicine 2021cited by 716position: middledoi
Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease
Brain 2021cited by 570position: middledoi
Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease
JAMA Neurology 2021cited by 305position: middledoi
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
Brain 2021cited by 219position: middledoi
Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s disease
Translational Psychiatry 2021cited by 154position: middledoi
A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis
European Journal of Nuclear Medicine and Molecular Imaging 2021cited by 79position: middledoi
Sex differences in off-target binding using tau positron emission tomography
NeuroImage Clinical 2021cited by 39position: firstdoi
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
JAMA 2020cited by 1,488position: middledoi
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
Nature Communications 2020cited by 534position: middledoi
Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease
Science Advances 2020cited by 366position: middledoi
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease
Nature Communications 2020cited by 339position: middledoi
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease
Brain 2020cited by 212position: middledoi
Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease
JAMA Neurology 2020cited by 140position: middledoi
The impact of demographic, clinical, genetic, and imaging variables on tau PET status
European Journal of Nuclear Medicine and Molecular Imaging 2020cited by 50position: middledoi
Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load
Neurology 2020cited by 19position: middledoi
Distinct tau PET patterns in atrophy‐defined subtypes of Alzheimer's disease
Alzheimer s & Dementia 2019cited by 120position: middledoi
Predicting diagnosis and cognition with <sup>18</sup>F‐AV‐1451 tau PET and structural MRI in Alzheimer's disease
Alzheimer s & Dementia 2019cited by 95position: middledoi
Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity
eLife 2019cited by 95position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Oskar Hansson · Medical Research Council23 papers (2017–2025)Olof Strandberg · Lund University17 papers (2017–2025)Sebastian Palmqvist · Lund University16 papers (2017–2025)Rik Ossenkoppele · Lund University15 papers (2018–2025)Niklas Mattsson · Lund University14 papers (2017–2025)Erik Stomrud · Lund University13 papers (2020–2025)Gil D. Rabinovici · Harvard University9 papers (2018–2025)Shorena Janelidze · Lund University9 papers (2018–2025)Renaud La Joie · University Memory and Aging Center8 papers (2018–2025)Philip S. Insel · University of California, San Francisco7 papers (2017–2021)Henrik Zetterberg · Indian Institute of Science Bangalore7 papers (2017–2025)Chul Hyoung Lyoo · Gangnam Severance Hospital7 papers (2018–2024)Kaj Blennow · First Affiliated Hospital of Anhui Medical University7 papers (2017–2023)Antoine Leuzy · Lund University6 papers (2020–2024)Hanna Cho · Yonsei University6 papers (2018–2024)Jonas Jögi · Wallenberg Wood Science Center6 papers (2017–2023)Tomas Ohlsson · Skåne University Hospital5 papers (2017–2023)Bruce L. Miller · University at Buffalo, State University of New York4 papers (2018–2024)Michael Schöll · Wallenberg Wood Science Center4 papers (2017–2019)Alexa Pichet Binette · Montreal Neurological Institute and Hospital4 papers (2022–2025)