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Hugo M. Horlings

The Netherlands Cancer Institute ·
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Area of research
Oncology · Cancer Research
Research interest
Research interests include Cancer Immunotherapy and Biomarkers, Cancer Genomics and Diagnostics, Cancer Cells and Metastasis, and Ovarian cancer diagnosis and treatment.
h-index
62
citations
25,601
works
389
NIH funding
primary concept
email

Recent publications

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC
Nature Cancer 2026cited by 2position: middledoi
Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 8position: middledoi
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial
Nature Medicine 2024cited by 63position: middledoi
Tumor-Infiltrating Lymphocytes in Patients With Stage I Triple-Negative Breast Cancer Untreated With Chemotherapy
JAMA Oncology 2024cited by 44position: middledoi
Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer
The Journal of Pathology 2024cited by 16position: middledoi
Abstract 3894: The temporal influence of the tumor microenvironment in response to checkpoint blockade
Cancer Research 2024cited by 1position: middledoi
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer
The Journal of Pathology 2023cited by 49position: middledoi
Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer
The Journal of Pathology 2023cited by 49position: middledoi
CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1
Cancer Cell 2023cited by 44position: middledoi
Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers
Nature Communications 2022cited by 44position: middledoi
CCNE1 and survival of patients with tubo‐ovarian high‐grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study
Cancer 2022cited by 43position: middledoi
Effect of <scp>HIPEC</scp> according to <scp>HRD</scp>/<scp><i>BRCA</i>wt</scp> genomic profile in stage <scp>III</scp> ovarian cancer: Results from the phase <scp>III OVHIPEC</scp> trial
International Journal of Cancer 2022cited by 42position: middledoi
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
npj Breast Cancer 2021cited by 268position: middledoi
MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 2021cited by 23position: middledoi
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
npj Breast Cancer 2020cited by 204position: middledoi
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
npj Breast Cancer 2020cited by 166position: middledoi
The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Molecular Cancer Research 2020cited by 62position: middledoi
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
npj Breast Cancer 2020cited by 19position: middledoi
Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer
Breast Cancer Research 2019cited by 51position: middledoi
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Advances in Anatomic Pathology 2017cited by 795position: middledoi
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research
Advances in Anatomic Pathology 2017cited by 713position: middledoi
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
Nature 2017cited by 697position: middledoi
Cancer-Associated Mutations in Endometriosis without Cancer
New England Journal of Medicine 2017cited by 612position: middledoi
HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
Genome Medicine 2015cited by 153position: middledoi
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets
Genome biology 2014cited by 68position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Marleen Kok · The Netherlands Cancer Institute4 papers (2019–2024)Gabe S. Sonke · Amsterdam University of the Arts2 papers (2022–2024)Marc J. van de Vijver · Amsterdam University of Applied Sciences2 papers (2014–2019)Sabine C. Linn · University Medical Center Utrecht2 papers (2020–2024) · 2 papers (2019–2024)Roberto Salgado · Université Libre de Bruxelles2 papers (2019–2024)Lodewyk F.A. Wessels · Oncode Institute2 papers (2014–2017)Jelle J. ten Hoeve · Center for Cancer Research1 papers (2014–2014)Sara Balduzzi · University of Fribourg1 papers (2024–2024)Wout De Wispelaere · KU Leuven1 papers (2022–2022)Daniela Annibali · KU Leuven1 papers (2022–2022)Peter Carmeliet · KU Leuven1 papers (2022–2022)Aleksandra Mihailović · Johns Hopkins University1 papers (2014–2014) · 1 papers (2019–2019)Christine Desmedt · KU Leuven1 papers (2019–2019)Thalia A. Farazi · Bristol-Myers Squibb (Germany)1 papers (2014–2014)Albert J. R. Heck · Utrecht University1 papers (2017–2017)Michiel de Maaker · Universitat de Barcelona1 papers (2019–2019)Christos Sotiriou · University of California San Diego1 papers (2019–2019)Riccardo Mezzadra · Oncode Institute1 papers (2017–2017)
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