Area of research
Molecular Biology · Plant Science
Research interest
Research topics from publications: Rare oxoisoaporphine alkaloids from Menispermum dauricum with potential anti-inflammatory activity; Triterpenoids from the fruits of Melia toosendan Sieb. et Zucc. with α-glucosidase inhibitory activities. Representative work: Four previously unreported tirucallane-type triterpenoids (1–4), together with four known analogues (5–8), were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their planar structures were comprehensively elucidated by detailed analyses of HRESIMS, 1D and 2D NMR spectra data. The relative configurations of 1–4 were determined by NOESY experiments. The comparison of experimental and calculated electronic circular dichroism (ECD) spectra led to the establishment of the absolute configurations of new compounds. All isolated triterpenoids were evaluated for their α-glucosidase inhibitory activities in vitro. Compounds 4 and 5 showed moderate α-glucosidase inhibitory activities with IC