Area of research
Cell Biology · Molecular Biology
Research interest
Research interests include Lipid Membrane Structure and Behavior, Cellular Mechanics and Interactions, Cellular transport and secretion, and Neuroscience and Neuropharmacology Research.
Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets.
Formation of extracellular vesicles depends on mechanical feedback of the cortex and the glycocalyx
Structural basis of caveolin-driven membrane bending
A predictive mechanochemical modeling framework for the deformation and remodeling of the nuclear lamina
Interplay between cortical adhesion and membrane bending regulates the formation of microparticles.
Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus.
Membrane curvature initiates Cdc42-FBP17-N-WASP clustering and actin nucleation.
A balance between nucleating and elongating actin filaments controls deformation of protein condensates.
Mitochondrial mechanics nucleates axonal jamming and swelling
Drosophila embryo cellularization is tuned by the viscoelastic properties of membrane-cortex linkers
A finite element framework for solving coupled multiphysics problems with moving boundaries in cell biophysics
The Evolution of Systems Biology and Systems Medicine: From Mechanistic Models to Uncertainty Quantification
Liquid-like condensates that bind actin promote assembly and bundling of actin filaments
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture
Spatial modeling algorithms for reactions and transport in biological cells.
Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time.
Increasing certainty in systems biology models using Bayesian multimodel inference.
Coupling between membrane undulations and lipid curvature leads to transient local enrichment of cardiolipin in mitochondrial membranes
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture.
Local enrichment of cardiolipin to transient membrane undulations.
A balance between nucleating and elongating actin filaments controls deformation of protein condensates
Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets
Spine apparatus modulates Ca<sup>2+</sup> in spines through spatial localization of sources and sinks.
Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx.
Systems modeling reveals that store-operated calcium entry modulates force and fatigue during exercise
Obstacles regulate membrane tension propagation to enable localized mechanotransduction
A FINITE ELEMENT FRAMEWORK FOR BULK-SURFACE COUPLED PDES TO SOLVE MOVING BOUNDARY PROBLEMS IN BIOPHYSICS <sup>*</sup>
Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.
Systems modeling of mitochondrial dynamics in different exercise regimes
Glycocalyx-induced formation of membrane tubes.
Collaborative Research: MODULUS: Protein droplets drive membrane bending and cytoskeletal organization
Collaborative Research: MODULUS: Modeling and Experimental Investigation of Protein Crowding on Lipid Bilayers
Collaborative Research: Isothermal Phase Transition in Lipid Vesicles and Swell-Burst Cycles
Mechbio Symposium: Finding the Pieces, Building the Puzzle; University of California-San Diego; La Jolla, California; August 4-5, 2016