Area of research
Molecular Biology · Oncology
Research interest
Research interests include Extracellular vesicles in disease, Cancer Cells and Metastasis, MicroRNA in disease regulation, and Immune cells in cancer.
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load
Tumour extracellular vesicles and particles induce liver metabolic dysfunction
Immune determinants of the pre-metastatic niche
Genomic mapping of metastatic organotropism in lung adenocarcinoma
Tumor-derived nanoseeds condition the soil for metastatic organotropism
Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism
Collection of Biospecimens from the Inspiration4 Mission Establishes the Standards for the Space Omics and Medical Atlas (SOMA)
Extracellular vesicles and particles impact the systemic landscape of cancer
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression
Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain
Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses
Calcium signaling induces a partial EMT
The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma
An exosome pathway without an ESCRT
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers
Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids
Exosome-Mediated Metastasis: Communication from a Distance