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Thorsten Mielke

Max Planck Institute for Molecular Genetics · DE
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Area of research
Molecular Biology · Ecology
Research interest
Research interests include RNA and protein synthesis mechanisms, RNA modifications and cancer, RNA Research and Splicing, and Bacteriophages and microbial interactions.
h-index
54
citations
8,581
works
193
NIH funding
primary concept
email

Recent publications

Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling
Communications Biology 2025cited by 8position: middledoi
Author Correction: A critical period of translational control during brain development at codon resolution
Nature Structural & Molecular Biology 2025cited by 1position: middledoi
Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Nature Communications 2025cited by 1position: middledoi
Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM
Nature Communications 2024cited by 14position: middledoi
Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution
Nucleic Acids Research 2024cited by 8position: middledoi
Cryo-EM captures early ribosome assembly in action
Nature Communications 2023cited by 46position: middledoi
Structure of the actively translating plant 80S ribosome at 2.2 Å resolution
Nature Plants 2023cited by 32position: middledoi
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
iScience 2023cited by 15position: middledoi
Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor
The EMBO Journal 2023cited by 10position: middledoi
A critical period of translational control during brain development at codon resolution
Nature Structural & Molecular Biology 2022cited by 61position: middledoi
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon
Science 2022cited by 61position: middledoi
Alternative splicing of BUD13 determines the severity of a developmental disorder with lipodystrophy and progeroid features
Genetics in Medicine 2022cited by 7position: middledoi
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
Cell Research 2021cited by 92position: middledoi
Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
PLoS Pathogens 2021cited by 16position: middledoi
Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit
Molecular Cell 2020cited by 53position: middledoi
Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma
Cancer Research 2020cited by 26position: middledoi
Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin
iScience 2020cited by 24position: middledoi
Current limits of structural biology: The transient interaction between cytochrome c and photosystem I
Current Research in Structural Biology 2020cited by 21position: middledoi
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
Nature Communications 2019cited by 98position: middledoi
tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis
Cell Reports 2018cited by 100position: middledoi
Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution
Molecular Cell 2018cited by 66position: middledoi
It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
Open Biology 2018cited by 40position: middledoi
Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6
Nature Communications 2018cited by 15position: middledoi
Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks
Scientific Reports 2017cited by 10position: middledoi
Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes
Genome Biology and Evolution 2015cited by 92position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

C.M.T. Spahn · Humboldt-Universität zu Berlin15 papers (2018–2025)Jörg Bürger · Humboldt-Universität zu Berlin14 papers (2018–2024)J. Loerke · Humboldt-Universität zu Berlin6 papers (2018–2024) · 5 papers (2017–2025)Patrick Scheerer · Humboldt-Universität zu Berlin4 papers (2018–2023)Tarek Hilal · Freie Universität Berlin4 papers (2018–2022)Matthias Selbach · Weatherford College4 papers (2020–2025)Markus Landthaler · Institute for Medical Biology3 papers (2020–2025)Magdalena Schacherl · Humboldt-Universität zu Berlin3 papers (2021–2024)Ulrike Zinnall · Max Delbrück Center3 papers (2020–2025)Thiemo Sprink · Max Delbrück Center3 papers (2020–2024)Mateusz C. Ambrozkiewicz · Charité - Universitätsmedizin Berlin3 papers (2020–2025)Екатерина Борисова · Humboldt-Universität zu Berlin3 papers (2020–2025)Uwe Ohler · Max Delbrück Center3 papers (2020–2025)Matthew L. Kraushar · Charité - Universitätsmedizin Berlin3 papers (2020–2025)Victor Tarabykin · Humboldt-Universität zu Berlin3 papers (2020–2025)Agnieszka Münster‐Wandowski · Charité - Universitätsmedizin Berlin3 papers (2020–2025)Andrea Schmidt · Humboldt-Universität zu Berlin3 papers (2018–2023)Dermot Harnett · Max Delbrück Center3 papers (2020–2025)Koshi Imami · Charité - Universitätsmedizin Berlin3 papers (2020–2025)
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