Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Retinal Development and Disorders, Photoreceptor and optogenetics research, Receptor Mechanisms and Signaling, and Retinal Diseases and Treatments.
Lipid-nanoparticle-mediated base editing of the trabecular meshwork rescues glaucoma in vivo
A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina.
Structural analysis of rhodopsin states in megabody complexes.
Light-Activated RPE65 Inhibitors Enable On-Demand Visual Cycle Control
Age-Driven Lipid Remodeling Activates Lysosome-Mediated Plasma Membrane Repair
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations.
Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.
Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma.
TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches.
MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids.
Insights into the Activation and Self-Association of Arrestin-1.
Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon Adiponectin Receptor 1 Depletion.
Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies.
Retinol tracing within murine neural retina reveals cell type–specific retinol transport and distribution
Scalable purification enables high-quality virus-like particles for therapeutic translation
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo.
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice.
Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins
Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice
Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration
Identification of shared gene expression programs activated in multiple modes of torpor across vertebrate clades
Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.