Area of research
Physiology · Cell Biology
Research interest
Research interests include Alzheimer's disease research and treatments, Cellular transport and secretion, Neuroinflammation and Neurodegeneration Mechanisms, and Pluripotent Stem Cells Research.
The Alzheimer's Disease Gene <i>SORL1</i> Regulates Lysosome Function in Human Microglia
Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
Pharmacologic enhancement of retromer rescues endosomal pathology induced by defects in the Alzheimer’s gene SORL1
Alternative splicing in a presenilin 2 variant associated with Alzheimer disease
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations
Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA
The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells
Investigating the relationship between the AD risk gene SORL1 and TDP-43 pathology in Alzheimer's Disease
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 3
Characterization of AD-related endolysosomal dysfunction in human neural cells
Characterization of AD-related endolysosomal dysfunction in human neural cells
Characterization of AD-related endolysosomal dysfunction in human neural cells
Postdoctoral Fellowship: STEMEdIPRF: Constructing a model and a measure of students' goal orientation in undergraduate chemistry courses
Mapping the landscape of the aged human brain for neurodegenerative disease models
Mapping the landscape of the aged human brain for neurodegenerative disease models
Regulation of diverse microglial phenotypes in neurodegeneration
Functions of Tau protein in human neural cells
Functions of Tau protein in human neural cells
Dissecting the role of sex-linked genes and APOE e4 risk in AD
Dissecting the role of sex-linked genes and APOE e4 risk in AD
Dissecting the role of sex-linked genes and APOE e4 risk in AD
Dissecting the role of sex-linked genes and APOE e4 risk in AD
Dissecting the role of sex-linked genes and APOE e4 risk in AD
Engineering Human Brain Neurovascular Niche for Modeling Brain Diseases
Engineering Human Brain Neurovascular Niche for Modeling Brain Diseases
Supporting Science Inquiry, Interest, and STEM Thinking for Young Dual Language Learners
Biological Mechanisms of Healthy Aging Training Grant
Biological Mechanisms of Healthy Aging Training Grant
Biological Mechanisms of Healthy Aging Training Grant
Biological Mechanisms of Healthy Aging Training Grant
Young Mathematicians: Expanding an Innovative and Promising Model Across Learning Environments to Promote Preschoolers' Mathematics Knowledge
Role of HDAC2 as a modulator of aging and Alzheimer's disease phenotypes in stem-cell derived neurons