Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Enzyme Structure and Function, Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, and Receptor Mechanisms and Signaling.
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor
Structural basis of BAK sequestration by MCL-1 in apoptosis
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP
Structure of human drug transporters OATP1B1 and OATP1B3
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase
Architecture of the cytoplasmic face of the nuclear pore
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1
Structure of an AMPK complex in an inactive, ATP-bound state
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins
Development of “Plug and Play” Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins
Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling