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Diane Lipscombe

Allen Institute for Brain Science · US
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Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Ion channel regulation and function, Neuroscience and Neuropharmacology Research, Pain Mechanisms and Treatments, and RNA Research and Splicing.
h-index
37
citations
7,456
works
118
NIH funding
primary concept
email

Recent publications

A bioluminescent activity dependent platform, BLADe, for converting intracellular activity to photoreceptor activation
Scientific Reports 2026cited by 0position: middledoi
CaBLAM: a high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase
Nature Methods 2025cited by 9position: middledoi
Control of Synaptic Communication through Molecularly Engineered Bioluminescence Light Emission and Sensing
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 2position: middledoi
<i>Trpv1</i> -dependent <i>Cacna1b</i> gene inactivation reveals cell-specific functions of Ca <sub>V</sub> 2.2 channels <i>in vivo</i>
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 1position: lastdoi
Efficient opto- and chemogenetic control in a single molecule driven by FRET-modified bioluminescence
Neurophotonics 2024cited by 10position: middledoi
Engineering luminopsins with improved coupling efficiencies
Neurophotonics 2024cited by 8position: middledoi
Interleukin-1α links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin
Scientific Reports 2024cited by 7position: lastdoi
Peripheral Ca <sub>V</sub> 2.2 Channels in the Skin Regulate Prolonged Heat Hypersensitivity during Neuroinflammation
eNeuro 2024cited by 4position: lastdoi
Peripheral Ca <sub>V</sub> 2.2 channels in skin regulate prolonged heat hypersensitivity during neuroinflammation
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 1position: lastdoi
CaBLAM! A high-contrast bioluminescent Ca <sup>2+</sup> indicator derived from an engineered <i>Oplophorus gracilirostris</i> luciferase
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 9position: middledoi
Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in <i>Sod1</i> mutant mouse model of ALS
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 6position: middledoi
A New Highly Efficient Molecule for Both Optogenetic and Chemogenetic Control Driven by FRET Amplification of BioLuminescence
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 3position: middledoi
A Bioluminescent Activity Dependent Platform, BLADe, for Converting Intracellular Activity to Photoreceptor Activation
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 3position: middledoi
Engineering luminopsins with improved coupling efficiencies
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 2position: middledoi
Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 2position: middledoi
ω-Phonetoxins inhibit voltage-gated calcium Ca <sub>V</sub> 2.2 ion channel splice isoforms of dorsal root ganglia
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 0position: middledoi
Interleukin-1α links peripheral Ca <sub>V</sub> 2.2 channel activation to rapid adaptive increases in heat sensitivity in skin
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 0position: lastdoi
Selective control of synaptically-connected circuit elements by all-optical synapses
Communications Biology 2022cited by 25position: middledoi
Analysing an allelic series of rare missense variants of <i>CACNA1I</i> in a Swedish schizophrenia cohort
Brain 2021cited by 36position: middledoi
Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated Ca<sub>V</sub>2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin
Journal of Neuroscience 2021cited by 22position: lastdoi
Bioluminescent optogenetic (BL-OG) activation of neurons during mouse postnatal brain development
STAR Protocols 2021cited by 10position: middledoi
Selective Control of Synaptically-Connected Circuit Elements by All-Optical Synapses
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 5position: middledoi
Developing biolight-based molecular technologies for simultaneous mapping, imaging, and controlling neural activity
Biophotonics Congress 2021 2021cited by 0position: middledoi
Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function
eLife 2020cited by 43position: lastdoi
Framework for advancing rigorous research
eLife 2020cited by 26position: middledoi
Epigenetic control of ion channel expression and cell-specific splicing in nociceptors: Chronic pain mechanisms and potential therapeutic targets
Channels 2020cited by 15position: firstdoi
Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals
2020cited by 11position: middledoi
Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 5position: middledoi
Peripheral voltage-gated calcium channels in skin are essential for transient neurogenic thermal hyperalgesia in mice
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 1position: lastdoi
Author response: Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function
2020cited by 0position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Christopher I. Moore · Allen Institute for Brain Science15 papers (2020–2026)Nathan C. Shaner · University of California San Diego14 papers (2020–2025)Ute Hochgeschwender · Central Michigan University12 papers (2020–2024) · 11 papers (2021–2026)Eduardo Javier López Soto · North Carolina State University11 papers (2017–2021) · 11 papers (2021–2025)Jeremy W. Murphy · Allen Institute for Brain Science8 papers (2020–2024)Nina Friedman · Allen Institute for Brain Science7 papers (2020–2024)Andreas Björefeldt · Brown University7 papers (2021–2024)Manuel Gomez‐Ramirez · Brown University6 papers (2020–2026) · 6 papers (2023–2026)Gerard G. Lambert · University of California San Diego6 papers (2023–2025)Akash Pal · University of California, Davis5 papers (2021–2026)Arturo Andrade · Allen Institute for Brain Science4 papers (2017–2025)Anne-Mary N. Salib · Allen Institute for Brain Science4 papers (2023–2024)Meredith J. Crane · Brown University4 papers (2023–2024)Dmitrijs Celinskis · Allen Institute for Brain Science4 papers (2020–2023)A. M. Jamieson · John Brown University4 papers (2023–2024) · 4 papers (2023–2024)Anne C. Hart · Allen Institute for Brain Science3 papers (2017–2018)
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