Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer Genomics and Diagnostics, RNA modifications and cancer, Lung Cancer Treatments and Mutations, and Epigenetics and DNA Methylation.
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
The evolution of lung cancer and impact of subclonal selection in TRACERx
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
The evolution of non-small cell lung cancer metastases in TRACERx
Body composition and lung cancer-associated cachexia in TRACERx
Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution
Refphase: Multi-sample reference phasing reveals haplotype-specific copy number heterogeneity
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Pervasive chromosomal instability and karyotype order in tumour evolution
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
The National Lung Matrix Trial of personalized therapy in lung cancer
A clonal expression biomarker associates with lung cancer mortality
Chromosomal instability drives metastasis through a cytosolic DNA response
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Tracking the Evolution of Non–Small-Cell Lung Cancer
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment