Area of research
Pathology and Forensic Medicine · Molecular Biology
Research interest
Research interests include Alcohol Consumption and Health Effects, Mitochondrial Function and Pathology, Liver Disease Diagnosis and Treatment, and Circadian rhythm and melatonin.
Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness
Relaxed targeting rules help PIWI proteins silence transposons
GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins
Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment
Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice
Thermus thermophilus Argonaute Functions in the Completion of DNA Replication
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure
Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver
The circadian clock and liver function in health and disease
Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice
Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet
IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling
Emerging role of circadian clock disruption in alcohol-induced liver disease
Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease
Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice
The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease
Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells
Physiological processes underlying organ injury in alcohol abuse
Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism
The Molecular Circadian Clock and Alcohol-Induced Liver Injury
Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice
The Bioenergetic Health Index: a new concept in mitochondrial translational research
Circadian regulation of metabolism
Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats
Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice
Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology
Chronic Ethanol Consumption Disrupts the Core Molecular Clock and Diurnal Rhythms of Metabolic Genes in the Liver without Affecting the Suprachiasmatic Nucleus
Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics