Area of research
Infectious Diseases · Epidemiology
Research interest
Research interests include Tuberculosis Research and Epidemiology, Mycobacterium research and diagnosis, Cytokine Signaling Pathways and Interactions, and interferon and immune responses.
Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred mice
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
Cell state transition analysis identifies interventions that improve control of <i>Mycobacterium tuberculosis</i> infection by susceptible macrophages
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice
Visualizing the dynamics of tuberculosis pathology using molecular imaging
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection
The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma
SP110b Controls Host Immunity and Susceptibility to Tuberculosis
Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity
New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies
Lung necrosis and neutrophils reflect common pathways of susceptibility to<i>Mycobacterium tuberculosis</i>in genetically diverse, immune competent mice
Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas
The sst1 Resistance Locus Regulates Evasion of Type I Interferon Signaling by Chlamydia pneumoniae as a Disease Tolerance Mechanism
Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis
Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity