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Xavier Leleu

Université de Poitiers · FR
Area of research
Hematology · Genetics
Research interest
Research interests include Multiple Myeloma Research and Treatments, Chronic Lymphocytic Leukemia Research, Protein Degradation and Inhibitors, and Cancer Treatment and Pharmacology.
h-index
94
citations
42,952
works
1,200
NIH funding
primary concept
email

Recent publications

Daratumumab-bortezomib-thalidomide-dexamethasone for newly diagnosed myeloma: CASSIOPEIA minimal residual disease results
Blood 2025cited by 21position: middledoi
International Myeloma Working Group immunotherapy committee consensus guidelines and recommendations for optimal use of T-cell-engaging bispecific antibodies in multiple myeloma
The Lancet Oncology 2024cited by 109position: middledoi
Bortezomib, thalidomide, and dexamethasone with or without daratumumab and followed by daratumumab maintenance or observation in transplant-eligible newly diagnosed multiple myeloma: long-term follow-up of the CASSIOPEIA randomised controlled phase 3 trial
The Lancet Oncology 2024cited by 107position: middledoi
Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies
Blood 2024cited by 42position: middledoi
Isatuximab plus carfilzomib–dexamethasone versus carfilzomib–dexamethasone in patients with relapsed multiple myeloma (IKEMA): overall survival analysis of a phase 3, randomised, controlled trial
The Lancet Haematology 2024cited by 21position: middledoi
Idecabtagene Vicleucel (Ide-cel) in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) with an Inadequate Response to Front-Line Autologous Stem Cell Transplantation (ASCT): KarMMa-2 Cohort 2c Extended Follow-up
Blood 2024cited by 7position: middledoi
MM-522 Effectiveness of Bridging Therapy Corresponds to Improved Outcomes After Receiving CAR-T Therapy: Phase 3 CARTITUDE-4 Study of Patients With Relapsed, Lenalidomide-Refractory Multiple Myeloma
Clinical Lymphoma Myeloma & Leukemia 2024cited by 2position: middledoi
Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma
New England Journal of Medicine 2023cited by 693position: middledoi
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
New England Journal of Medicine 2023cited by 492position: middledoi
Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study
Blood Cancer Journal 2023cited by 94position: middledoi
Final analysis of carfilzomib, dexamethasone, and daratumumab vs carfilzomib and dexamethasone in the CANDOR study
Blood Advances 2023cited by 90position: middledoi
Efficacy and safety of elranatamab in patients with relapsed/refractory multiple myeloma (RRMM) and prior B-cell maturation antigen (BCMA)-directed therapies: A pooled analysis from MagnetisMM studies.
Journal of Clinical Oncology 2023cited by 41position: middledoi
Comparative Efficacy of Teclistamab Versus Current Treatments in Real-World Clinical Practice in the Prospective LocoMMotion Study in Patients with Triple-Class-Exposed Relapsed and/or Refractory Multiple Myeloma
Advances in Therapy 2023cited by 28position: middledoi
Isatuximab plus carfilzomib and dexamethasone in patients with early <i>versus</i> late relapsed multiple myeloma: IKEMA subgroup analysis
Haematologica 2023cited by 15position: middledoi
Comparative Effectiveness of Teclistamab Versus Real-World Physician’s Choice of Therapy in LocoMMotion and MoMMent in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma
Advances in Therapy 2023cited by 11position: middledoi
Anti-CD38 antibody therapy for patients with relapsed/refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes
Annals of Hematology 2022cited by 64position: firstdoi
KarMMa-2 Cohort 2a: Efficacy and Safety of Idecabtagene Vicleucel in Clinical High-Risk Multiple Myeloma Patients with Early Relapse after Frontline Autologous Stem Cell Transplantation
Blood 2022cited by 51position: middledoi
Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 Maia Study
Blood 2022cited by 41position: middledoi
Efficacy and safety of teclistamab (tec), a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients (pts) with relapsed/refractory multiple myeloma (RRMM) after exposure to other BCMA-targeted agents.
Journal of Clinical Oncology 2022cited by 40position: middledoi
Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial
The Lancet 2021cited by 376position: middledoi
Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma (MAIA): overall survival results from a randomised, open-label, phase 3 trial
The Lancet Oncology 2021cited by 356position: middledoi
Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group
The Lancet Oncology 2021cited by 266position: middledoi
Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial
The Lancet Oncology 2021cited by 173position: middledoi
Expert review on soft‐tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations
British Journal of Haematology 2021cited by 171position: middledoi
A phase 2 study of isatuximab monotherapy in patients with multiple myeloma who are refractory to daratumumab
Blood Cancer Journal 2021cited by 89position: lastdoi
P-193: Elotuzumab plus pomalidomide/dexamethasone for relapsed/refractory multiple myeloma: final overall survival from the phase 2 ELOQUENT-3 trial
Clinical Lymphoma Myeloma & Leukemia 2021cited by 5position: middledoi
Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial
The Lancet 2020cited by 319position: middledoi
Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial
Journal of Clinical Oncology 2020cited by 78position: middledoi
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma
New England Journal of Medicine 2019cited by 978position: middledoi
Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
The Lancet 2019cited by 631position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Philippe Moreau · CEA Cadarache15 papers (2012–2024)Meletios Α. Dimopoulos · Korea University8 papers (2014–2024)Salomon Manier · CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers8 papers (2012–2024)Aurore Perrot · Institut Universitari de Ciencia i Tecnologia (Spain)7 papers (2019–2024)Thierry Façon · Inserm7 papers (2012–2024)Lionel Karlin · Bristol-Myers Squibb (Switzerland)6 papers (2019–2024)Saad Z. Usmani · Weill Cornell Medicine5 papers (2022–2024)Katja Weisel · National Institute Of Blood Disease and Bone Marrow Transplantation5 papers (2014–2023)Ivan Špıčka · Charles University5 papers (2020–2024)Nizar J. Bahlis · University of Calgary4 papers (2022–2024)Hang Quach · National and Kapodistrian University of Athens4 papers (2020–2023)Michel Delforge · Erasmus MC Cancer Institute4 papers (2014–2023)Kenshi Suzuki · Jikei University School of Medicine4 papers (2018–2024)Jesús F. San Miguel · Centro de Investigación Biomédica en Red de Cáncer4 papers (2014–2022)Irene M. Ghobrial · Harvard University4 papers (2012–2017)Ravi Vij · Columbia University4 papers (2012–2024)Paul G. Richardson · Harvard University4 papers (2017–2022)Noopur Raje · Harvard University3 papers (2022–2023)Albert Oriol · Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo3 papers (2020–2024)Britta Besemer · Center for Rheumatology3 papers (2022–2024)