Area of research
Rheumatology · Molecular Biology
Research interest
Research topics from publications: S1P/S1PR1 axis promotes macrophage M1 polarization through NLRP3 inflammasome activation in Lupus nephritis; SIRT1 slows the progression of lupus nephritis by regulating the NLRP3 inflammasome through ROS/TRPM2/Ca2+ channel; Role of sphingosine-1-phosphate mediated signalling in systemic lupus erythematosus; Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone‐Induced Damage by Intermedin through Activation of Wnt/β‐Catenin Signaling Pathway; The p70S6K/PI3K/MAPK feedback loop releases the inhibition effect of high-dose rapamycin on rat mesangial cell proliferation. Representative work: Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally administrated by intravenous infusion which is liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. Intermedin (IMD), a member of calcitonin family, has a broad spectrum of biological effects including anti‐inflammatory effects, antioxidant activities, and antiapoptosis. But now, the protective effects of IMD against amiodarone‐induced phlebitis and the underlying molecular mechanism are not well understood. In this study, the aim was to investigate the protective efficiency and potential mechanisms of IMD in amiodarone‐induced phlebitis. The results of this study Glomerular mesangial cell (MC) proliferation is one of the causative factors of glomerular diseases and one of their prominent pathological features. Rapamycin can inhibit MC proliferation and slow the progression to chronic renal fibrosis. The present study was designed to observe the role of rapamycin in MC proliferation and to explore the mechanism by which rapamycin acts on Akt and MAPK/ERK1/2 pathways in mesangial cells. MTT assay and flow cytometry were used to evaluate the proliferation and the cell cycle phase of glomerular mesangial cells respectively. The mRNA expression level of p70S6K was detected by RT-qPCR. Western blotting was performed to determine p70S6K, PI3K/Akt, and PI3K/
S1P/S1PR1 axis promotes macrophage M1 polarization through NLRP3 inflammasome activation in Lupus nephritis
SIRT1 slows the progression of lupus nephritis by regulating the NLRP3 inflammasome through ROS/TRPM2/Ca2+ channel
Role of sphingosine-1-phosphate mediated signalling in systemic lupus erythematosus
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone‐Induced Damage by Intermedin through Activation of Wnt/<i>β</i>‐Catenin Signaling Pathway
The p70S6K/PI3K/MAPK feedback loop releases the inhibition effect of high-dose rapamycin on rat mesangial cell proliferation