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Lawrence J. Appel

Johns Hopkins University Applied Physics Laboratory · US
Area of research
Public Health, Environmental and Occupational Health · Nutrition and Dietetics
Research interest
As for my own research, I have conducted clinical research with a particular focus on preventing and controlling elevated blood pressure, and its consequences, primarily cardiovascular and kidney diseases. I have four active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes, often related to obesity, (3) cohort studies and trials related to chronic kidney disease and its consequences, and (4) global implementation initiatives to prevent and control hypertension. A notable feature of my research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.
h-index
135
citations
97,680
works
1,088
NIH funding
primary concept
email

Recent publications

Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration
JAMA Network Open 2025cited by 10position: middledoi
Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group
Circulation 2025cited by 6position: middledoi
Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC)
PLoS Medicine 2025cited by 5position: middledoi
Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease
JACC Advances 2025cited by 4position: middledoi
Incident heart failure in chronic kidney disease: proteomics informs biology and risk stratification
European Heart Journal 2024cited by 19position: middledoi
Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity
Annals of Internal Medicine 2024cited by 17position: middledoi
Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
American Journal of Kidney Diseases 2024cited by 12position: middledoi
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
JCI Insight 2024cited by 12position: middledoi
Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study
Kidney Medicine 2024cited by 12position: middledoi
Five‐Year Cumulative Cardiovascular Health and Clinical Events in Patients With Chronic Kidney Disease: The CRIC Study
Journal of the American Heart Association 2024cited by 3position: middledoi
Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes
JAMA 2023cited by 291position: firstdoi
Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease
JAMA 2023cited by 44position: middledoi
Adherence to Plant-Based Diets and Risk of CKD Progression and All-Cause Mortality: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
American Journal of Kidney Diseases 2023cited by 40position: middledoi
Ultraprocessed Foods and Kidney Disease Progression, Mortality, and Cardiovascular Disease Risk in the CRIC Study
American Journal of Kidney Diseases 2023cited by 34position: middledoi
Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study
Annals of Internal Medicine 2023cited by 31position: middledoi
Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function
Kidney International 2023cited by 28position: middledoi
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study
Nephrology Dialysis Transplantation 2023cited by 18position: middledoi
Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study
Kidney Medicine 2023cited by 17position: middledoi
Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial
American Journal of Kidney Diseases 2023cited by 16position: middledoi
Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
American Journal of Kidney Diseases 2023cited by 14position: middledoi
Relationship of calcium and magnesium intakes with the dietary approaches to stop hypertension score and blood pressure: the International Study of Macro/micronutrients and Blood Pressure
Journal of Hypertension 2023cited by 9position: middledoi
The association between changes in echocardiography and risk of heart failure hospitalizations and death in adults with chronic kidney disease
Scientific Reports 2023cited by 4position: middledoi
Early Outpatient Treatment for Covid-19 with Convalescent Plasma
New England Journal of Medicine 2022cited by 268position: middledoi
Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial
Clinical Infectious Diseases 2022cited by 39position: middledoi
Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D
Journal of the American Society of Nephrology 2022cited by 37position: middledoi
Blood pressure interactions with the DASH dietary pattern, sodium, and potassium: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)
American Journal of Clinical Nutrition 2022cited by 34position: middledoi
Association of Mitochondrial DNA Copy Number with Risk of Progression of Kidney Disease
Clinical Journal of the American Society of Nephrology 2022cited by 31position: middledoi
Prediction of Incident Heart Failure in CKD: The CRIC Study
Kidney International Reports 2022cited by 28position: middledoi
Self-reported Physical Activity and Cardiovascular Events in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study
American Journal of Kidney Diseases 2022cited by 27position: middledoi
Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
American Journal of Kidney Diseases 2022cited by 11position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Harold I. Feldman · University of Pennsylvania64 papers (2013–2024)James P. Lash · University of Illinois Chicago61 papers (2013–2024)Jiang He · Medical Research Council60 papers (2012–2024)Mahboob Rahman · University School60 papers (2014–2024)Alan S. Go · Kaiser Permanente58 papers (2014–2024)Raymond R. Townsend · Newcastle University58 papers (2012–2023)Panduranga S. Rao · University of Illinois Chicago40 papers (2018–2024)John W. Kusek · National Institute of Diabetes and Digestive and Kidney Diseases38 papers (2013–2024)Akinlolu Ojo · University of Kansas Medical Center25 papers (2012–2020)Dawei Xie · Capital Medical University24 papers (2012–2024)Amanda H. Anderson · Tulane University23 papers (2013–2024)Jing Chen · Tulane University23 papers (2012–2024)Chi‐yuan Hsu · Kaiser Permanente23 papers (2013–2023)Edgar R. Miller · Anna Needs Neuroblastoma Answers20 papers (2012–2023)Ana C. Ricardo · Illinois College20 papers (2016–2024)Myles Wolf · Duke University20 papers (2012–2023)Robert G. Nelson · Institute of Nutrition, Metabolism and Diabetes19 papers (2016–2024)Rajat Deo · Penn Center for AIDS Research18 papers (2016–2023)Nisha Bansal · University of Washington18 papers (2014–2023)Vallabh O. Shah · University of Illinois Chicago17 papers (2020–2024)