Area of research
Molecular Biology · Immunology
Research interest
Research interests include interferon and immune responses, Cancer, Hypoxia, and Metabolism, RNA modifications and cancer, and Ubiquitin and proteasome pathways.
Grass carp (Ctenopharyngodon idella) SMYD3 negatively regulates antiviral innate immunity by methylating IRF3 and IRF7 during GCRV infection.
Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity.
MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α.
Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7.
Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α.
Zebrafish hif1β attenuates antiviral innate immunity by suppressing Irf7 transcriptional activity.
Genetic evidence for the suppressive role of zebrafish vhl targeting mavs in antiviral innate immunity during RNA virus infection.
Human OCEL1 senses bacterial infection to unlock inflammatory responses.
Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3.
Zebrafish <i>phd1</i> enhances mavs-mediated antiviral responses in a hydroxylation-independent manner.
Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity.
Zebrafish mavs Is Essential for Antiviral Innate Immunity.
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage.
Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling.
OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation.
Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs.
Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
Zebrafish <i>prmt2</i> Attenuates Antiviral Innate Immunity by Targeting traf6.
Zebrafish <i>sirt7</i> Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity.
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation.
Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7.
Zebrafish NF-κB/p65 Is Required for Antiviral Responses.
Zebrafish Hif3α modulates erythropoiesis via regulation of <i>gata1</i> to facilitate hypoxia tolerance.
TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.
Zebrafish <i>phd3</i> Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity.
Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity.
Zebrafish <i>prmt5</i> arginine methyltransferase is essential for germ cell development.
Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model