Area of research
Molecular Biology · Computational Theory and Mathematics
Research interest
Research interests include Computational Drug Discovery Methods, Protein Structure and Dynamics, CAR-T cell therapy research, and Immunotherapy and Immune Responses.
Universal paratope-epitope interaction patterns in antibody-antigen structures.
Swiss-PO 2025: Advancing Cancer Mutation and Structural Analysis for Precision Oncology With the Latest Release.
Attracting Cavities 3.0: Faster and More Versatile Molecular Docking for the SwissDock Webserver
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms.
Phage display enables machine learning discovery of cancer antigen-specific TCRs.
Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer.
Author Correction: Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms.
Rapid and Reliable Structural Modeling of Adaptive Immune Receptors Using an Optimized AlphaFold3 workflow
Rethinking Molecular Beauty in the Deep Learning Era
Comparative Assessment of the Utility of Co-Folding and Docking for Small-Molecule Drug Design
Knowledge-guided machine-learning and reverse screening combined method to predict cancer cell line responses to cytotoxic molecules
Novel universal domain-centric method for protein classification
SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina.
Testing the predictive power of reverse screening to infer drug targets, with the help of machine learning.
Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Combining SiRPα decoy-coengineered T cells and antibodies augments macrophage-mediated phagocytosis of tumor cells.
Predicting Antigen-Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist.
Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.
Preclinical model for evaluating human TCRs against chimeric syngeneic tumors.
A direct experimental test of Ohno’s hypothesis
A direct experimental test of Ohno’s hypothesis
Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Methylation-Based Characterization of a New <i>IDH2</i> Mutation in Sinonasal Undifferentiated Carcinoma.
Author response: A direct experimental test of Ohno’s hypothesis
SwissParam 2023: A Modern Web-Based Tool for Efficient Small Molecule Parametrization
SwissParam 2023: A Modern Web-Based Tool for Efficient Small Molecule Parametrization.
Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.
Attracting Cavities 2.0: Improving the Flexibility and Robustness for Small-Molecule Docking.
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.
Influenza A virus exploits transferrin receptor recycling to enter host cells.