Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Congenital heart defects research, Cardiac Fibrosis and Remodeling, Tissue Engineering and Regenerative Medicine, and Cardiomyopathy and Myosin Studies.
Valve biology and rheumatic heart disease pathogenesis.
Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis.
Maturation of human cardiac organoids enables complex disease modeling and drug discovery
Maturation of human cardiac organoids enables complex disease modeling and drug discovery.
Muscle regeneration and muscle stem cells in metabolic disease.
Clinical Validity of Autosomal Dominant <i>ALPK3</i> Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy.
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.
Designing multicellular cardiac tissue engineering technologies for clinical translation.
Clinical Validity of Autosomal Dominant<i>ALPK3</i>Loss-of-function Variants as a Cause of Hypertrophic Cardiomyopathy
An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models.
Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset
Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function.
Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
Maturation of human cardiac organoids enables complex disease modelling and drug discovery
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues
Prenylation controls proliferation in human pluripotent stem cell-derived cardiomyocytes
Vascular cells improve functionality of human cardiac organoids
Vascular cells improve functionality of human cardiac organoids.
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
Disparities in spatially variable gene calling highlight the need for benchmarking spatial transcriptomics methods.
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment.
GLA-modified RNA treatment lowers GB3 levels in iPSC-derived cardiomyocytes from Fabry-affected individuals.
Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury
Generation of vascularized human cardiac organoids for 3D in vitro modeling.
Automated Integration of Multi-Slice Spatial Transcriptomics Data in 2D and 3D
Affinity purification-mass spectrometry and single fiber physiology/proteomics reveals mechanistic insights of C18ORF25
propeller: testing for differences in cell type proportions in single cell data.